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Gargi Sen, Research @ IICB, Kolkata

Country: India, Language: English
I offer: eryhtrocyte , visceral leishmaniasis, quercetin , bioavailability, Zinc toxicity, hepatocyte
Gargi Sen @ IICB, Kolkata

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Gargi Sen @ Kolkata
Jan 10  +

88 results for Gargi Sen

CiteULike: 14-Deoxyandrographolide desensitizes hepatocytes to TNFα-induced apoptosis through calcium-dependent TNFRSF1A release via the NO/cGMP pathway

D. N. Roy, S. Mandal, G. Sen, S. Mukhopadhyay, T. Biswas. British Journal of Pharmacology, Vol. 9999, No. 999A. (2010). Background and purpose: Andrographis paniculata (AP) has been found to display hepatoprotective effect, although the mechanism of action of the active compounds of AP in this context still remains unclear. Here, we evaluated the hepatoprotective efficacy of 14-deoxyandrographolide (14-DAG), a bioactive compound of AP, paticularly its role in desensitization of hepatocytes to TNF03B1-induced signalling of apoptosis.Experimental approach: TNF03B1-mediated ligand receptor interaction in hepatocytes in presence of 14-DAG was studied in vitro in primary hepatocyte cultures, with the help of co-immunoprecipitation, confocal microscopy and FACS analysis. Events associated with 14-DAG-induced TNFRSF1A release from hepatocytes were determined using immunoblotting, biochemical assay and fluorimetric studies. Pulse-chase experiments with radiolabelled TNF03B1 and detection of apoptotic nuclei by TUNEL labelling were performed under in vivo conditions.Key results: 14-DAG down-regulated the formation of death-inducing signalling complex (DISC), resulting in desensitization of hepatocytes to TNF03B1-induced apoptosis. Pretreatment of hepatocytes with 14-DAG accentuated microsomal Ca-ATPase activity through induction of NO/cGMP pathway. This resulted in enhanced calcium influx into microsomal lumen with the formation of TNFRSF1A-ARTS-1-NUCB2 complex in cellular vesicles. It was followed by the release of full length 55kDa TNFRSF1A and a reduction in the number of cell surface TNFRSF1A, which eventually caused diminution of TNF03B1 signal in hepatocytes.Conclusion and Implication: Taken together, the results demonstrate for the first time that 14-DAG desensitizes hepatocytes to TNF03B1-mediated apoptosis through the release of TNFRSF1A. This can be used as a strategy against cytokine-mediated hepatocyte apoptosis in liver dysfunctions.
Gargi Sen @ Kolkata
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citeulike.org 2010-05-15  +  

Invalid URL: Wiley InterScience :: Session Cookies

This is an Accepted Article that has been peer-reviewed and approved for publication in the British Journal of Pharmacology, but has yet to undergo copy-editing and proof correction. Please cite this article as an "Accepted Article"; doi: 10.1111/j.1476-5381.2010.00836.x Copyright Journal compilation © 2010 The British Pharmacological Society
Gargi Sen @ Kolkata
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.interscience.wiley.com 2010-05-09  +  

Cambridge Journals Online


Gargi Sen @ Kolkata
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journals.cambridge.org 2010-03-17  +  

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Gargi Sen @ Kolkata
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researchgate.net 2010-02-18  +  

Journal de Physique IV

Journal de Physique IV, archive
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jp4.journaldephysique.org 2010-02-15  +  

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Gargi Sen @ Kolkata
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researchgate.net 2010-02-09  +  

Your new biomedical search engine – Novoseek

Novoseek is a free biomedical search engine. Search for relevant biomedical information in scientific journals in MEDLINE, in Full Text publications from Open Access in PubMedCentral or for US awarded grants from the NIH and many other sources. Novoseek is easy and intuitive to use and it relies on semantic technology to extract relevant information adding meaning to the searches that you currently perform in sites like PubMed. The real alternative to Pubmed for scientists, librarians, medical doctors and life science professionals.
Gargi Sen @ Kolkata
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novoseek.com 2010-02-09  +  

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Gargi Sen @ Kolkata
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researchgate.net 2010-02-09  +  

Journal of Postgraduate Medicine: Reviewers Team

Dr. R Gafoor, Psychiatry. Dr. R Gallego, Nephrology. Dr. R Goldin, Pathology. Dr. R Gourdie, Cell Biology. Dr. R Grady, Urology. Dr. R Greenstein, Surgery ...
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jpgmonline.com 2010-01-28  +  

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